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Pragmatic trials are those that are designed to provide information for the practice of clinical trials in real life. They are typically focused on the practical aspects of study design, including the recruitment and consent process, adherence, and the use of standard equipment.
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A pragmatic trial that uses a variety investigators and includes participants from various geographical regions is the Home Blood Pressure Management study (HBPM). This kind of heterogeneity, which is vital for pragmatic trials to be reliable and reduce bias in results, is also necessary. However too much heterogeneity could result in issues with the design of the trial.
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Pragmatic Play offers not only mobile-friendly slot machines, but also table games and live casino. Pragmatic Play is licensed and is regulated by various regulatory bodies that include the Malta Gaming Authority and UK Gambling Commission. Its games are backed by high-end encryption and the security team is ready to assist players solve any issues they might face.
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Legality
Pragmatic Play is known for its top-notch games, and also for providing an outstanding user experience. Its software is designed to work on mobile devices and supports various languages. It has established itself as one of the top casino gaming platforms despite its relative youth. The most recent releases include Wolves which is a five-reel video slot with a healthy RTP and stunning graphics. The other notable titles include Wolf Gold and Chilli Heat.
The purpose of pragmatic trials is to simulate real-life scenarios and gain the highest level of validity externally. Usually, they are requested by practitioners and policymakers to guide their decisions. They can also be used to assess the causality of an intervention with its outcomes. However, they should not be used to substitute for explanatory studies.
The pragmatism concept is controversial and there are doubts about whether pragmatic trials should be used to replace explanatory trials or complement them. Schwartz and Lellouch1 proposed the distinction between explanation studies, which support the physiological hypothesis or clinical hypothesis, as well as pragmatic trials, which inform policy and practice decision-making. They also proposed a framework called PRECIS for pragmatic trials.2 The tool was designed to define the elements of a practical study, including recruitment, design, implementation of the intervention, and follow-up.
The number of pragmatic trials is growing. A recent Medline search using the terms naturalistic and pragmatic, limited to controlled trials randomized to control (RCTs) resulted in 34 articles, which are shown in red in Figure 2. This is an indication that the health science community is becoming more sensitive to the subject of pragmatic thinking. However, it is important to remember that the majority of these studies were conducted in primary care settings.